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University of Bedfordshire
Park Square
Luton
Bedfordshire
UK, LU1 3JU
BSc (Hons), PhD
Senior Lecturer in Biomedical/Forensic Science
Dr John Reynolds is currently a Senior Lecturer in Biomedical/Forensic Science within the Division of Science based at the Park Square campus of the University of Bedfordshire in Luton.
After obtaining a BSc (Hons) in Biology from the University of Strathclyde in Glasgow, John did a PhD in the Renal Unit within the Department of Medicine at the Royal Postgraduate Medical School at Hammersmith Hospital, supervised by Professor Charles Pusey.
Since the completion of his PhD, John has been involved in several postdoctoral collaborative studies, while based in the Renal Section within the Division of Medicine at the Hammersmith Campus of Imperial College London.
He had a laboratory placement in Professor Tim Aitman's Laboratory at the MRC Clinical Sciences Centre, Imperial College London, and was a visiting scientist in Professor Raghu Kalluri's Laboratory at the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston.
As a result, John was appointed as a Research Lecturer at Imperial College London in May 2008, and moved to the University of Bedfordshire to take up a Senior Lecturer appointment in March 2010.
John is the Chairman of the Renal Scientists Working Party, and the Scientific Representative on the National Executive Committee, the Education and Training Committee and the Research Committee of The Renal Association.
In general my research interests have focused on the investigation of the immunopathogenesis and assessment of antibody-based therapeutic approaches in animal models of autoimmunity.
More recently, my research has focused on investigating novel approaches to both antigen-specific and non-antigen-specific immunotherapy in animal models of autoimmune renal disease.
In antigen specific therapy, my major contributions have been to identify an immunodominant peptide, and demonstrate that nasal administration of this peptide is capable of inducing mucosal tolerance.
In non-antigen-specific therapy, I have demonstrated that blocking the ICOS T cell costimulatory pathway, or stimulating the PD1 T cell costimulatory pathway are both effective in the treatment of established disease.
At present I am developing a programme of research investigating which regulatory populations of T cells are responsible for the induction of mucosal tolerance in these therapeutic studies, and to examine which signalling pathways may be involved in controlling these novel T cell costimulatory pathways.
