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University of Bedfordshire
Park Square
Luton
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To apply for a research degree, please make sure you fulfill the entry requirements and then complete the online research degree application form and upload your supporting documents.
You should have a good honours degree (2:1 or above) or masters degree or equivalent in the relevant subject area.
International applicants should be aware of our research degree English language requirements
ContraCancrum will develop a composite multilevel platform for simulating malignant tumour development and tumour and normal tissue response to therapeutic modalities and treatment schedules.
The project will have an impact primarily by providing:
(a) a better understanding of the natural phenomenon of cancer at different levels of biocomplexity and, most importantly,
(b) a disease treatment optimization procedure in the patient's individualized context by simulating the response to various therapeutic regimes.
The predictions of the simulators to be developed will rely on imaging, histopathological, molecular and clinical data of the patient. Fundamental biological mechanisms involved in tumour development and the response of tumour/normal tissue to treatment, such as metabolism, cell cycle, tissue mechanics, cell survival following treatment, etc., will be modelled. Stem cells will be addressed in the context of both tumour and normal tissue behaviour.
From the mathematical point of view, the simulators will exploit several discrete and continuous mathematics methods such as cellular automata, the generic Monte Carlo technique, finite elements, differential equations, novel dedicated algorithms etc.
A study of the analogies of tumour growth with embryological development is expected to provide insights into both mechanisms. ContraCancrum will deploy two important clinical studies for validating the models, one on lung cancer and one on gliomas. The crucial validation work will be based on comparing the multi-level therapy simulation predictions with the actual medical data (including medical images), acquired before and after therapy.
ContraCancrum will pave the way in translating multilevel cancer models into clinical practice.
In ContraCancrum, CCGV will provide Web services and other infrastructure support to enable the various resources within the project, which will be distributed at a variety of locations, to communicate effectively. It will also provide a range of visualisation services and support general-purpose GPU-based (GPGPU) computation for cancer modelling.
