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University of Bedfordshire
Park Square
Luton
Bedfordshire
UK, LU1 3JU
To apply for a research degree, please make sure you fulfill the entry requirements and then complete the online research degree application form and upload your supporting documents.
You should have a good honours degree (2:1 or above) or masters degree or equivalent in the relevant subject area.
International applicants should be aware of our research degree English language requirements
This project will complement VPHOP by developing a complete morphable model of the musculoskeletal system. A generic surface model of the musculoskeletal system will be automatically adapted to fit exactly the patient anatomy as defined in medical images. The resulting anatomical model will be fused with patient motion data that define the kinematics of the skeleton during various physical activities.
For each time frame, the new algorithm will compute the wrapping of each muscle by imposing volume preservation and the impenetrability of muscles and bone. The resulting wrapped muscle volumes will then be decomposed into a chaff of parallel lines of action based on fibre orientation (muscle pennation). The muscle pennation will be derived directly from imaging data optimised using GPU programming, so that it can run in quasi-real-time, even for a large number of muscle volumes. If the available imaging does not provide the basic information, the muscle pennation will be derived from that defined in the initial generic model, derived from cadaver studies.
Once achieved, this objective will make it possible to include in clinical practice protocols based on predictive technology, goals relevant not only to the general objectives of the VPHOP project (which targets osteoporotic fractures) but also to a wide range of neuromusculoskeletal diseases ranging from paediatric cerebral palsy to skeletal oncology and degenerative diseases of significant social impact such as back pain or osteoarthritis.
