Senior Lecturer in Immunology
I joined the School of Life Sciences in March 2015 from University College London (UCL), where I was a Senior Research Associate.
Prior to this I undertook postdoctoral training at Imperial College London and UCL. I completed my PhD (Immunology) and MRes (Biomedical Sciences) degrees at Imperial College following my BSc (Clinical Sciences) at King’s College London.
I was born, raised and schooled in Luton and have an interest in widening local participation in science education.
I am a Fellow of the Higher Education Academy and I teach on several undergraduate courses in the School of Life Sciences. I am course co-ordinator for MSc Microbiology in Public Health and am also postgraduate research degrees co-ordinator for the University's Institute of Biomedical and Environmental Science & Technology (iBEST). I have supervised MRes, MSc and PhD projects and was involved in postgraduate teaching throughout my time at UCL.
I enjoy interacting with students at all levels, aiming to capture interest and stimulate curiosity! I find teaching immunology particularly rewarding; as a research-active immunologist I draw on my professional expertise and personal enthusiasm for the subject.
I am interested in cell differentiation, cell-to-cell communication, and the role of tissue-derived proteins in influencing immune cell function. My research has focused on investigating the signals that instruct T-cells, either during their development in the thymus, or in peripheral tissues during activation or T-helper cell differentiation. My published work has contributed to the understanding of T-cell selection and signalling, autoimmunity, and allergic responses.
In 2013 I was awarded a personal fellowship by Asthma UK to investigate the modulation of immune responses by Hedgehog signalling in allergic asthma. I retain strong collaborative links with colleagues at UCL and have also established research projects with colleagues within the University of Bedfordshire.
Recent Publications (last five years)
- 1) Davies EG, Cheung M, Gilmour K, Maimaris J, Curry J, Furmanski A, Sebire N, Halliday N, Mengrelis K, Adams S, Bernatoniene J, Bremner R, Browning M, Devlin B, Erichsen HC, Gaspar HB, Hutchison L, Ip W, Ifversen M, Leahy TR, McCarthy E, Moshous D, Neuling K, Pac M, Papadopol A, Parsley KL, Poliani L, Ricciardelli I, Sansom DM, Voor T, Worth A, Crompton T, Markert ML, Thrasher AJ., Thymus transplantation for complete DiGeorge syndrome: European experience. Journal of Allergy and Clinical Immunology, 2017 Dec;140(6):1660-1670
- 2) Standing ASI, Yanez D, Ross R, Crompton T & Furmanski AL, Frontline Science: Shh signalling and Gli signalling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma, Journal of Leukocyte Biology, 2017 Oct; 102(4): 965-976
- 3) Saldana JI, Solanki A, Lau CI, Sahni H, Ross SE, Furmanski AL, Ono M, Hollander G & Crompton T, Sonic Hedgehog regulates thymic epithelial cell differentiation, Journal of Autoimmunity, 2016 Apr;68:86-97
- 4) Sahni H, Ross S, Barbarulo A, Solanki A, Lau CI, Furmanski A, Saldaña JI, Ono M, Hubank M, Barenco M, Crompton T, A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation, Oncotarget, 2015 Oct 6;6(30):28646-60
- 5) Furmanski AL and Crompton T, Gli2, Hedgehog and TCR signalling, Oncotarget, 2015 Sep 22;6(28):24592-3
- 6) Furmanski AL*, Barbarulo A, Sahni H, Saldana JI, D’Acquisto F & Crompton T, The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity, Journal of Cell Science, 2015 Jun 1;128(11):2085-95
- 7) Falconer J, Lowes K, Furmanski A, Dyson PJ, Ng W-F, Robinson J, Intramolecular polyspecificity in CD4 T-cell recognition of Ad-restricted epitopes of proteoglycan aggrecan, Immunology, May 2014, 142(1):101
- 8) Hager-Theodorides AL, Ross SE, Sahni H, Mishina Y, Furmanski AL & Crompton T, Direct BMP2/4 signaling through BMP receptor IA regulates fetal thymocyte progenitor homeostasis and differentiation to CD4+CD8+ double-positive cell, Cell Cycle, 2013 13;3
- 9) Furmanski AL, Saldana JI, Ono M, Sahni H, Paschalidis N, D’Acquisto F and Crompton T, Tissue-derived Hedgehog proteins modulate Th differentiation and disease, Journal of Immunology, 2013 Mar 15, 190(6):2641
- 10) Furmanski AL, O’Shaughnessey R, Saldana JI, Blundell M, Thrasher A, Sebire N, Davies EG and Crompton T, T-cell reconstitution following thymus xenotransplantation induces hair depigmentation and loss, Journal of Investigative Dermatology, 2013 May, 133(5):1221
T: +44 (0)1582 743575